**Voom** is an R function that transforms the input count data into log2-counts per million, estimates the mean-variance relationship and uses this information to compute observational level weights to prepare data for linear modeling in limma.

voom(counts, design = NULL, lib.size = NULL, normalize.method = "none", span = 0.5, plot = FALSE, save.plot = FALSE, ...)

*References:*

Law, CW, Chen, Y, Shi, W, Smyth, GK (2014). Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. *Genome Biology* 15, R29.**http://genomebiology.com/2014/15/2/R29**