What is voom?

Mean-variance modeling at the observational level

Voom is an R function that transforms the input count data into log2-counts per million, estimates the mean-variance relationship and uses this information to compute observational level weights to prepare data for linear modeling in limma.

References:

Law, CW, Chen, Y, Shi, W, Smyth, GK (2014). Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biology 15, R29.http://genomebiology.com/2014/15/2/R29